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apalutamide will lessen the extent or impact of modafinil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. Coadministration of apalutamide, a robust CYP3A4 inducer, with medicine that are CYP3A4 substrates can lead to reduced exposure to these medicines.It is not regarded no matter whether modafinil passes in

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